Ph.D. program: “Splice site recognition mechanisms and regulators”
The SABNP laboratory is an INSERM research unit working on the structure and function of RNA:Protein complexes with the aim to foster applications in medicine and biotechnology. To that end, the SABNP laboratory develops an integrative approach encompassing structural biology, bioinformatics and cell biology to enlighten the role of RNA-binding proteins related to cancer (YB-1, Lin28, HuR, SF3b155, etc.) and neurodegenerative diseases (TDP-43, FUS, PUF60, etc.). The research is organized into four closely related themes dealing with mRNA translation, alternative splicing, RNA-binding proteins involved in neurodegenerative diseases, and the development of bioinformatics as an analytical tool combined with structural data.
Furthermore, we develop new methods to interrogate inaccessible information. Notably we have developed a new technology that makes use of microtubules as nanoplatforms to probe biomolecular interactions in cells and to observe sub-compartmentalization of RNA-binding proteins along microtubules. We also propose new technologies to enable the development of fluorescent nanodiamonds in biology and propose methods to analyze RNA for diagnostic purposes. These researches, pre-maturation and maturation projects, allow the opportunity to launch startups in partnership with Genopole.