Abrakhi, S., Kretov, D.A., Desforges, B., Dobra, I., Bouhss, A., Pastre, D. and Hamon, L. (2017) Nanoscale analysis reveals the maturation of neurodegeneration-associated protein aggregates: grown in mRNA granules then released by stress granule proteins. ACS nano, 11, 7189-7200.

Plaud, C., Joshi, V., Marinello, M., Pastré, D., Galli, T., Curmi, P. and Burgo, A. (2017) Spastin regulates VAMP7-containing vesicles trafficking in cortical neurons. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1863, 1666-1677.

Hadj-Rabia, S., Brideau, G., Al-Sarraj, Y., Maroun, R.C., Figueres, M.-L., Leclerc-Mercier, S., Olinger, E., Baron, S., Chaussain, C. and Nochy, D. (2017) Multiplex epithelium dysfunction due to CLDN10 mutation: the HELIX syndrome. Genetics in medicine: official journal of the American College of Medical Genetics.

Vermeer, L.S., Hamon, L., Schirer, A., Schoup, M., Cosette, J., Majdoul, S., Pastré, D., Stockholm, D., Holic, N. and Hellwig, P. (2017) Vectofusin-1, a Potent Peptidic Enhancer of Viral Gene Transfer forms pH-dependent α-Helical Nanofibrils, Concentrating Viral Particles. Acta biomaterialia.

Jarroux, N., Clément, M., Gervais, M., Moriau, S., Maciejak, O., Curmi, P. and Cheradame, H. (2017) Templated polycondensation of aminopropyltrimethoxysilane on DNA. European Polymer Journal.

Alawdi, S.H., El-Denshary, E.S., Safar, M.M., Eidi, H., David, M.-O. and Abdel-Wahhab, M.A. (2017) Neuroprotective effect of nanodiamond in Alzheimer’s disease rat model: a pivotal role for modulating NF-κB and STAT3 signaling. Molecular neurobiology, 54, 1906-1918.

R.C. Maroun (2017). “Why computational methods for the study of biological macromolecules and their effectors?” Boletín Médico del Hospital Infantil de México. 5-Jan-2017. DOI: 10.1016 /j.bmhimx. 2016.10.005.


Hamon L, Savarin P, Pastre D (2016) Polyamine signal through gap junctions: A key regulator of proliferation and gap-junction organization in mammalian tissues? BioEssays : news and reviews in molecular, cellular and developmental biology, 38: 498-507.

Mephon-Gaspard A, Boca M, Pioche-Durieu C, Desforges B, Burgo A, Hamon L, Pietrement O, Pastre D (2016) Role of tau in the spatial organization of axonal microtubules: keeping parallel microtubules evenly distributed despite macromolecular crowding. Cellular and molecular life sciences : CMLS, 73: 3745-3760.

Sari-Hassoun M, Clement MJ, Hamdi I, Bollot G, Bauvais C, Joshi V, Toma F, Burgo A, Cailleret M, Rosales-Hernandez MC, Macias Perez ME, Chabane-Sari D, Curmi PA (2016) Cucurbitacin I elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-kinase. Biochemical pharmacology, 102: 45-63.

Sukhanova MV, Abrakhi S, Joshi V, Pastre D, Kutuzov MM, Anarbaev RO, Curmi PA, Hamon L, Lavrik OI (2016) Single molecule detection of PARP1 and PARP2 interaction with DNA strand breaks and their poly(ADP-ribosyl)ation using high-resolution AFM imaging. Nucleic acids research,44: e60.

Bakalov, V., Amathieu, R., Triba, MN, Clément MJ, Reyes Uribe, L., Le Moyec, L., Murat Kaynar, A. (2016) Metabolomics with Nuclear Magnetic Resonance Spectroscopy in a Drosophila melanogaster Model of Surviving Sepsis. Metabolites, 6,47.

Niel, R., Ayachi, M., Mille-Hamard, L., Le Moyec, L., Savarin, P., Clément, MJ, Besse, S., Launay, T., Billat, VL, Momken, I. (2016) A new model of short acceleration- based training improves exercise performance in old mice. Scandinavian Journal of Medicine & Science in Sports, doi: 10.1111/sms.12809.

Blin, F., Przybylski, C., Bonnet, V., Clément, MJ, Curmi, PA, Choppinet, P., Nakajima, T., Cheradame, H., Jarroux, N. (2016) Radical Coupling Allows a Fast and Tuned Synthesis of Densely Packed Polyrotaxanes Involving gamma-Cyclodextrins and Polydimethylsiloxane. Macromolecules, 49:3232-3243.

Chatrikhi, R., Wang, W., Gupta, A., Loerch, S., Maucuer, A., Kielkopf, CL. (2016) SF1 Phosphorylation Enhances Specific Binding to U2AF65 and Reduces Binding to 3′-Splice-Site RNA.
Biophys J. 111(12):2570-2586. doi: 10.1016/j.bpj.2016.11.007.

Crépeaux, G., Eidi, H., David, M.-O., Giros, B., Authier, F.-J., Exley, C., Shaw, C., Cadusseau, J. and Gherardi, R.K. (2016) Low concentrations of aluminum hydroxide adjuvant, forming limited size aggregates, selectively induce cerebral aluminum increase and long-term neurotoxicity in mouse. Morphologie, 100, 160-161.


Kretov, D.A., Curmi, P.A., Hamon, L., Abrakhi, S., Desforges, B., Ovchinnikov, L.P. and Pastre, D. (2015) mRNA and DNA selection via protein multimerization: YB-1 as a case study. Nucleic acids research, 43, 9457-9473.

Kljashtorny, V., Nikonov, S., Ovchinnikov, L., Lyabin, D., Vodovar, N., Curmi, P. and Manivet, P. (2015) The Cold Shock Domain of YB-1 Segregates RNA from DNA by Non-Bonded Interactions. PloS one, 10, e0130318.

Huynh, L., Perrot, N., Beswick, V., Rosilio, V., Curmi, P.A., Sanson, A. and Jamin, N. (2015) Reply to “Comment on ‘Structural properties of POPC monolayers under lateral compression: computer simulations analysis'”. Langmuir : the ACS journal of surfaces and colloids, 31, 888-889.

Fomina, E.E., Pestryakov, P.E., Kretov, D.A., Zharkov, D.O., Ovchinnikov, L.P., Curmi, P.A. and Lavrik, O.I. (2015) Inhibition of abasic site cleavage in bubble DNA by multifunctional protein YB-1. Journal of molecular recognition : JMR, 28, 117-123.

Eidi, H., David, M.O., Crepeaux, G., Henry, L., Joshi, V., Berger, M.H., Sennour, M., Cadusseau, J., Gherardi, R.K. and Curmi, P.A. (2015) Fluorescent nanodiamonds as a relevant tag for the assessment of alum adjuvant particle biodisposition. BMC medicine, 13, 144.

Crepeaux, G., Eidi, H., David, M.O., Tzavara, E., Giros, B., Exley, C., Curmi, P.A., Shaw, C.A., Gherardi, R.K. and Cadusseau, J. (2015) Highly delayed systemic translocation of aluminum-based adjuvant in CD1 mice following intramuscular injections. Journal of inorganic biochemistry, 152, 199-205.

Boca, M., Kretov, D.A., Desforges, B., Mephon-Gaspard, A., Curmi, P.A. and Pastre, D. (2015) Probing protein interactions in living mammalian cells on a microtubule bench. Scientific reports, 5, 17304.

Alemasova, E.E., Pestryakov, P.E., Sukhanova, M.V., Kretov, D.A., Moor, N.A., Curmi, P.A., Ovchinnikov, L.P. and Lavrik, O.I. (2015) Poly(ADP-ribosyl)ation as a new posttranslational modification of YB-1. Biochimie, 119, 36-44.

Méndez-Luna D, Martínez-Archundia M, Maroun RC, Ceballos-Reyes G, Fragoso-Vázquez MJ, González-Juárez DE, Correa-Basurto J. (2015). “Deciphering the GPER/GPR30-agonist and antagonists interactions using molecular modeling studies, molecular dynamics, and docking simulations.” JBiomol  Struct Dyn. Jan 14:1-12. PMID: 25587872.


Kambouris, M., Maroun, R.C., Ben-Omran, T., Al-Sarraj, Y., Errafii, K., Ali, R., Boulos, H., Curmi, P.A. and El-Shanti, H. (2014) Mutations in zinc finger 407 [ZNF407] cause a unique autosomal recessive cognitive impairment syndrome. Orphanet journal of rare diseases, 9, 80.

Huynh, L., Perrot, N., Beswick, V., Rosilio, V., Curmi, P.A., Sanson, A. and Jamin, N. (2014) Structural properties of POPC monolayers under lateral compression: computer simulations analysis. Langmuir : the ACS journal of surfaces and colloids, 30, 564-573.

Bounedjah, O., Desforges, B., Wu, T.D., Pioche-Durieu, C., Marco, S., Hamon, L., Curmi, P.A., Guerquin-Kern, J.L., Pietrement, O. and Pastre, D. (2014) Free mRNA in excess upon polysome dissociation is a scaffold for protein multimerization to form stress granules. Nucleic acids research, 42, 8678-8691.


Pastre, D., Joshi, V., Curmi, P.A. and Hamon, L. (2013) Detection of single DNA molecule hybridization on a surface by atomic force microscopy. Small, 9, 3630-3638.

Lefevre, J., Savarin, P., Gans, P., Hamon, L., Clement, M.J., David, M.O., Bosc, C., Andrieux, A. and Curmi, P.A. (2013) Structural basis for the association of MAP6 protein with microtubules and its regulation by calmodulin. The Journal of biological chemistry, 288, 24910-24922.

Fassier, C., Tarrade, A., Peris, L., Courageot, S., Mailly, P., Dalard, C., Delga, S., Roblot, N., Lefevre, J., Job, D. et al. (2013) Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knockout mice. Disease models & mechanisms, 6, 72-83.

Desforges, B., Curmi, P.A., Bounedjah, O., Nakib, S., Hamon, L., De Bandt, J.P. and Pastre, D. (2013) An intercellular polyamine transfer via gap junctions regulates proliferation and response to stress in epithelial cells. Molecular biology of the cell, 24, 1529-1543.


Merstorf C, Maciejak O, Mathé J, Pastoriza-Gallego M, Thiebot B, Clément MJ,Pelta J, Auvray L, Curmi PA, Savarin P. Mapping the conformational stability ofmaltose binding protein at the residue scale using nuclear magnetic resonancehydrogen exchange experiments. Biochemistry. 2012 Nov 6;51(44):8919-30. doi:10.1021/bi3003605. Epub 2012 Oct 24. PubMed PMID: 23046344.

Fassier C, Tarrade A, Peris L, Courageot S, Mailly P, Dalard C, Delga S,Roblot N, Lefèvre J, Job D, Hazan J, Curmi PA, Melki J. Microtubule-targetingdrugs rescue axonal swellings in cortical neurons from spastin knockout mice. DisModel Mech. 2013 Jan;6(1):72-83. doi: 10.1242/dmm.008946. Epub 2012 Jul 5. PubMedPMID: 22773755; PubMed Central PMCID: PMC3529340.

Saidi Brikci-Nigassa A, Clement MJ, Ha-Duong T, Adjadj E, Ziani L, Pastre D, Curmi PA, Savarin P. Phosphorylation controls the interaction of the connexin43C-terminal domain with tubulin and microtubules. Biochemistry. 2012 May29;51(21):4331-42. doi: 10.1021/bi201806j. Epub 2012 May 14. PubMed PMID:22558917.

André JR, Clément MJ, Adjadj E, Toma F, Curmi PA, Manivet P. The state of theguanosine nucleotide allosterically affects the interfaces of tubulin inprotofilament. J Comput Aided Mol Des. 2012 Apr;26(4):397-407. doi:10.1007/s10822-012-9566-x. Epub 2012 Apr 19. PubMed PMID: 22527959.

Pestryakov P, Zharkov DO, Grin I, Fomina EE, Kim ER, Hamon L, Eliseeva IA,Petruseva IO, Curmi PA, Ovchinnikov LP, Lavrik OI. Effect of the multifunctional proteins RPA, YB-1, and XPC repair factor on AP site cleavage by DNA glycosylase NEIL1. J Mol Recognit. 2012 Apr;25(4):224-33. doi: 10.1002/jmr.2182. PubMed PMID:22434712.

Bounedjah O, Hamon L, Savarin P, Desforges B, Curmi PA, Pastré D.Macromolecular crowding regulates assembly of mRNA stress granules after osmotic stress: new role for compatible osmolytes. J Biol Chem. 2012 Jan20;287(4):2446-58. doi: 10.1074/jbc.M111.292748. Epub 2011 Dec 6. PubMed PMID:22147700; PubMed Central PMCID: PMC3268405.

Hamon L, Savarin P, Curmi PA, Pastré D. Rapid assembly and collectivebehavior of microtubule bundles in the presence of polyamines. Biophys J. 2011Jul 6;101(1):205-16. doi: 10.1016/j.bpj.2011.05.022. PubMed PMID: 21723831;PubMed Central PMCID: PMC3127188.

The state of the guanosine nucleotide allosterically affects the interfaces of tubulin in protofilament. André JR, Clément MJ, Adjadj E, Toma F, Curmi PA, Manivet P. J Comput Aided Mol Des, 26(4):397-407, 2012.

Effect of the multifunctional proteins RPA, YB-1, and XPC repair faction on AP site cleavage by DNA glycosylase NEIL1. Pestryakov P, Zharkov DO, Grin I, Fomina EE, Kim ER, Hamon L, Eliseeva IA, Petruseva IO, Curmi PA, Ovchinnikov LP, Lavrik OI. J Mol Recognit 25:224-233, 2012.

Macromolecular crowding regulates assembly of mRNA stress granules after osmotic stress: new role for compatible osmolytes. Bounedjah O, Hamon L, Savarin P, Desforges B, Curmi PA, Pastré D. J Biol Chem., 287(4):2446-58, 2012.


Rapid assembly and collective behavior of microtubule bundles in the presence of polyamines. Hamon L, Savarin P, Curmi PA, Pastré D. Biophys J. 101(1):205-16, 2011.

Gap junctions favor normal rat kidney epithelial cell adaptation to chronic hypertonicity. Desforges B, Savarin P, Bounedjah O, Delga S, Hamon L, Curmi PA, Pastré D. Am J Physiol Cell Physiol., 301(3):C705-16, 2011.

The C terminus of tubulin, a versatile partner for cationic molecules: binding of Tau, polyamines, and calcium. Lefèvre J, Chernov KG, Joshi V, Delga S, Toma F, Pastré D, Curmi PA, Savarin P. J Biol Chem.286(4):3065-78, 2011.


NMR characterization and molecular modeling of fucoidan showing the importance of oligosaccharide branching in its anticomplementary activity. Clément MJ, Tissot B, Chevolot L, Adjadj E, Du Y, Curmi PA, Daniel R. Glycobiology. 20(7):883-94, 2010.

Drosophila stathmins bind tubulin heterodimers with high and variable stoichiometries. Lachkar S, Lebois M, Steinmetz MO, Guichet A, Lal N, Curmi PA, Sobel A, Ozon S. J Biol Chem.,285(15):11667-80, 2010.

Specific DNA-protein interactions on mica investigated by atomic force microscopy.Pastré D, Hamon L, Sorel I, Le Cam E, Curmi PA, Piétrement O. Langmuir. 26(4):2618-23, 2010.

High-resolution imaging of microtubules and cytoskeleton structures by atomic force microscopy. Hamon L, Curmi PA, Pastré D. Methods Cell Biol. 95:157-74, Review, 2010.

Probing interactions of tubulin with small molecules, peptides, and protein fragments by solution nuclear magnetic resonance. Clément MJ, Savarin P, Adjadj E, Sobel A, Toma F, Curmi PA. Methods Cell Biol. 95:407-47. Review, 2010.

A central role for polyamines in microtubule assembly in cells. Savarin P, Barbet A, Delga S, Joshi V, Hamon L, Lefevre J, Nakib S, De Bandt JP, Moinard C, Curmi PA, Pastré D. Biochem J.430(1):151-9, 2010.

Investigation of DNA condensing properties of amphiphilic triblock cationic polymers by atomic force microscopy. Lidgi-Guigui N, Guis C, Brissault B, Kichler A, Leborgne C, Scherman D, Labdi S, Curmi PA. Langmuir. 26(22):17552-7, 2010.


Polyamine sharing between tubulin dimers favours microtubule nucleation and elongation via facilitated diffusion. Mechulam A, Chernov KG, Mucher E, Hamon L, Curmi PA, Pastré D. PLoS Comput Biol. 5(1):e1000255. Epub 2009 Jan 2.

The PN2-3 domain of centrosomal P4.1-associated protein implements a novel mechanism for tubulin sequestration. Cormier A, Clément MJ, Knossow M, Lachkar S, Savarin P, Toma F, Sobel A, Gigant B, Curmi PA. J Biol Chem. 284(11):6909-17, 2009.

Mica surface promotes the assembly of cytoskeletal proteins. Hamon L, Panda D, Savarin P, Joshi V, Bernhard J, Mucher E, Mechulam A, Curmi PA, Pastré D. Langmuir. 25(6):3331-5, 2009.

High yield fabrication of fluorescent nanodiamonds. Boudou JP, Curmi PA, Jelezko F, Wrachtrup J, Aubert P, Sennour M, Balasubramanian G, Reuter R, Thorel A, Gaffet E. Nanotechnology. 20(23):235602, 2009.

Fluorescence and Spin Properties of Defects in Single Digit Nanodiamonds. Tisler J, Balasubramanian G, Naydenov B, Kolesov R, Grotz B, Reuter R, Boudou JP, Curmi PA, Sennour M, Thorel A, Bo¨rsch M, Aulenbacher K, Erdmann R, Hemmer PR, Jelezko F, Wrachtrup J. ACS Nano. 3(7):1959-1965, 2009.

The stathmin-derived I19L peptide interacts with FtsZ and alters its bundling. Clément MJ, Kuoch BT, Ha-Duong T, Joshi V, Hamon L, Toma F, Curmi PA, Savarin P. Biochemistry. 48(41):9734-44, 2009.

Role of microtubules in stress granule assembly: microtubule dynamical instability favors the formation of micrometric stress granules in cells. Chernov KG, Barbet A, Hamon L, Ovchinnikov LP, Curmi PA, Pastré D. J Biol Chem. 284(52):36569-80, 2009.

Photoluminescent diamond nanoparticles for cell labeling: study of the uptake mechanism in mammalian cells. Faklaris O, Joshi V, Irinopoulou T, Tauc P, Sennour M, Girard H, Gesset C, Arnault JC, Thorel A, Boudou JP, Curmi PA, Treussart F. ACS Nano. 3(12):3955-62, 2009.


Benomyl and colchicine synergistically inhibit cell proliferation and mitosis: evidence of distinct binding sites for these agents in tubulin. Clément MJ, Rathinasamy K, Adjadj E, Toma F, Curmi PA, Panda D. Biochemistry. 47(49):13016-25, 2008.

Detection of single photoluminescent diamond nanoparticles incells and study of the internalization pathway. Faklaris O, Garrot D, Joshi V, Druon F, Boudou JP, Sauvage T, Georges P, Curmi PA, Treussart F. Small. 12:2236-9, 2008.

YB-1 promotes microtubule assembly in vitro through interaction with tubulin and microtubules. Chernov KG, Mechulam A, Popova NV, Pastre D, Nadezhdina ES, Skabkina OV, Shanina NA, Vasiliev VD, Tarrade A, Melki J, Joshi V, Baconnais S, Toma F, Ovchinnikov LP, Curmi PA. BMC Biochem. 15;9:23, 2008.

Both lipid environment and pH are critical for determining physiological solution structure of 3-D-conserved epitopes of the HIV-1 gp41-MPER peptide P1. Coutant J, Yu H, Clément MJ, Alfsen A, Toma F, Curmi PA, Bomsel M.. FASEB J. 12:4338-51, 2008.

Atomic force microscopy reveals binding of mRNA to microtubules mediated by two major mRNP proteins YB-1 and PABP. Chernov KG, Curmi PA, Hamon L, Mechulam A, Ovchinnikov LP, Pastré D. FEBS Lett. 582(19):2875-81, 2008.

Atomic force microscopy reveals binding of mRNA to microtubules mediated by two major mRNP proteins YB-1 and PABP. Chernov KG, Curmi PA, Hamon L, Mechulam A, Ovchinnikov LP, Pastré D. FEBS Lett. 2008 582:2875-81


NMR assignment of PN2-3, a tubulin interaction subdomain of the CPAP protein. Clément MJ, Savarin P, Coutant J, Toma J, Curmi P. Biomolecular NMR assignment, (DOI 10.1007/s12104-008-9099-3), 2008.

Atomic force microscopy imaging of DNA under macromolecular crowding conditions. Pastré D, Hamon L, Mechulam A, Sorel I, Baconnais S, Curmi PA, Le Cam E, Piétrement O. Biomacromolecules, 12:3712-7, 2007.

NMR solution structure of neurotensin in membrane-mimetic environments: molecular basis for neurotensin receptor recognition. Coutant J, Curmi PA, Toma F, Monti JP. Biochemistry. 46:5656-63, 2007.

Diamond nanoparticles as photoluminescent nanoprobes. Faklaris O, Sonnefraud Y, Cuche A, Sauvage T, Joshi V, Boudou JP, Curmi PA, Roch JF, Huant S, Treussart F. Annales de Physique 32: 2-3, 2007.

High-resolution AFM imaging of single-stranded DNA-binding (SSB) protein/DNA complexes. Hamon L, Pastré D, Dupaigne P, Le Breton C, Le Cam E, Piétrement O. Nucleic Acids Research, 35 (8), e58, 2007.

Switching Layer Stability in a Polymer Bilayer by Thickness Variation. de Silva JP, Geoghegan M, Higgins AM, Krausch G, David MO, Reiter G. ” Physical Review Letters 98: 267802, 2007.


Stathmin strongly increases the minus end catastrophe frequency and induces rapid treadmilling of bovine brain microtubules at steady state in vitro. Manna T, Thrower D, Miller HP, Curmi P, Wilson L. J Biol Chem., 281: 2071-2078, 2006.

Phosphorylation of the tubulin-binding protein, stathmin, by Cdk5 and MAP kinases in the brain. Hayashi K, Pan Y, Shu H, Ohshima T, Kansy JW, White CL 3rd, Tamminga CA, Sobel A, Curmi PA, Mikoshiba K, Bibb JA. J Neurochem. 99:237-250, 2006.

Polyelectrolyte adsorption on mica mediated by multivalent cations: a solution to DNA imaging by atomic force microscopy under high ionic strength. Pastré D, Hamon L, Landousy F, Sorel I, David MO, Zozime A, Le Cam E, Pietrement O. Langmuir, 22 :6651-6660, 2006.

The EcoRI-DNA Complex as a Model for Investigating Protein-DNA Interactions by Atomic Force Microscopy. Sorel I, Piétrement O, Hamon L, Baconnais S, Le Cam E, Pastré D. Biochemistry , 45:14675-14682, 2006.

A new approach to DNA bending by polyamines and its implication in DNA condensation. Pastré D , Pietrement O, Landousy F, Hamon L, Sorel I, David MO, Delain E, Zozime A, Le Cam E. EurBiophys., 35:214-223, 2006.

Activation of RNA metabolism-related genes in mouse but not human tissues deficient in SMN. Olaso R, Joshi V, Fernandez J, Roblot N, Courageot S, Bonnefont JP, Melki J. Physiol Genomics. 24:97-104, 2006.